Three‐dimensional histology vs. serial section histology in the treatment of primary basal cell carcinoma: a randomized, prospective, blinded study of 569 tumours

Background For basal cell carcinoma (BCC), only few controlled data have been published so far, which directly compare micrographically surgery with conventional serial section histology. In addition to Mohs surgery, uses cryostat sections, also three-dimensional histology (3D-histology), based on paraffin is available ensure complete control of the margins and basic sections. Objectives To investigate rate local recurrence (LR) as well number required re-excisions for carcinomas vs. 3D-histology. Methods We compared sections 3D-histology in a prospective, randomized, blinded trial analysed 569 BCC all subtypes up 30 mm diameter, 287 3D group 282 group. Excisions were performed adapted primary resection margin according location size tumour. Surgeons at time they did not know histological method will be used. Both methods used Results groups differ regarding patients age, tumour location, or margins. group, 21%; 24 tumours (8.4%) recurred after median 2.2 years. 39%; 10 (3.5%) 2.8 The rates differed significantly between both groups. Mean follow-up was 4.5 Conclusions useful technique detect outgrowths excision margins, but high re-excisions. associated lower LR than